cis-4-Azidomethyl-1-tert-butoxycarbonyl-3-methoxypiperidine → tert-Butyl (3S,4R)-4-(aminomethyl)-3-methoxypiperidine-1-carboxylate

Participants

Reaction Steps

To a solution of cis-4-azidomethyl-1-tert-butoxycarbonyl-3-methoxypiperidine (1.5 g) in methanol (50 ml) was added 20% palladium carbon hydroxide (0.6 g), and the resulting mixture was stirred at room temperature under hydrogen atmosphere for 2 hr. 20% Palladium carbon hydroxide was filtered off and the solvent was evaporated under reduced pressure to give 1.2 g of cis-4-aminomethyl-1-tert-butoxycarbonyl-3-methoxypiperidine.

Provenance & Evidence