Acetyl chloride → HCID 15840962, compound

HRID 344297Notes

Reaction equation

HRID 344297 reaction equation
C(O[C:6]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][NH2:19])[CH2:11]1)=[O:7])(C)(C)C.[C:20](Cl)(=[O:22])[CH3:21].[NH2:24][C:25]1[C:33]([Cl:34])=[CH:32][C:28](C(O)=O)=[C:27]([O:35][CH3:36])[CH:26]=1>>[C:20]([NH:19][CH2:18][CH2:17][CH2:16][CH2:15][N:12]1[CH2:13][CH2:14][CH:10]([CH2:9][NH:8][C:6](=[O:7])[C:28]2[CH:32]=[C:33]([Cl:34])[C:25]([NH2:24])=[CH:26][C:27]=2[O:35][CH3:36])[CH2:11]1)(=[O:22])[CH3:21]

Participants

4

Reactant 3

HCID 6367Acetyl chlorideHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53780052HCID 53780052, compound

Product 1

HCID 15840962HCID 15840962, compound

Procedure

4-(3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)butylamine (1.05 g) as starting compound was reacted and treated in the same manner as in Example 1 using acetyl chloride (0.30 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (0.78 g) to give N-(1-(4-acetylaminobutyl)pyrrolidin-3-ylmethyl)-4-amino-5-chloro-2-methoxybenzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-f2d529c677fb4f369459cfed37b27529
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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