Acetyl chloride → HCID 15840963, compound

HRID 344298Notes

Reaction equation

HRID 344298 reaction equation
C(O[C:6]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH2:20])[CH2:11]1)=[O:7])(C)(C)C.[C:21](Cl)(=[O:23])[CH3:22].[NH2:25][C:26]1[C:34]([Cl:35])=[CH:33][C:29](C(O)=O)=[C:28]([O:36][CH3:37])[CH:27]=1>>[C:21]([NH:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][N:12]1[CH2:13][CH2:14][CH:10]([CH2:9][NH:8][C:6](=[O:7])[C:29]2[CH:33]=[C:34]([Cl:35])[C:26]([NH2:25])=[CH:27][C:28]=2[O:36][CH3:37])[CH2:11]1)(=[O:23])[CH3:22]

Participants

4

Reactant 3

HCID 6367Acetyl chlorideHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53808196HCID 53808196, compound

Product 1

HCID 15840963HCID 15840963, compound

Procedure

5-(3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)pentylamine (0.99 g) as starting compound was reacted and treated in the same manner as in Example 1 using acetyl chloride (0.25 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (0.71 g) to give N-(1-(5-acetylaminopentyl)pyrrolidin-3-ylmethyl)-4-amino-5-chloro-2-methoxybenzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-7023346ddc954e6890ea12bd5cbaaaab
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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