Cyclohexanecarbonyl chloride → HCID 53637519, compound

HRID 344300Notes

Reaction equation

HRID 344300 reaction equation
C(O[C:6]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH2:18])[CH2:11]1)=[O:7])(C)(C)C.[CH:19]1([C:25](Cl)=[O:26])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1.[NH2:28][C:29]1[C:37]([Cl:38])=[CH:36][C:32](C(O)=O)=[C:31]([O:39][CH3:40])[CH:30]=1>>[NH2:28][C:29]1[C:37]([Cl:38])=[CH:36][C:32]([C:6]([NH:8][CH2:9][CH:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH:18][C:25]([CH:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)=[O:26])[CH2:11]2)=[O:7])=[C:31]([O:39][CH3:40])[CH:30]=1

Participants

4

Reactant 3

HCID 75938Cyclohexanecarbonyl chlorideHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53696622HCID 53696622, compound

Product 1

HCID 53637519HCID 53637519, compound

Procedure

3-(3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)propylamine (0.98g) as starting compound was reacted and treated in the same manner as in Example 1 using cyclohexanecarbonyl chloride (0.54 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (0.77 g) to give 4-amino-5-chloro-N-(1-(3-cyclohexanecarbonylaminopropyl)pyrrolidin-3-ylmethyl)-2-methoxybenzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-9e3b0b025cd2464dbb320cbaf4721243
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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