Cyclohexanecarbonyl chloride → HCID 54116413, compound

HRID 344301Notes

Reaction equation

HRID 344301 reaction equation
C(O[C:6]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][NH2:19])[CH2:11]1)=[O:7])(C)(C)C.[CH:20]1([C:26](Cl)=[O:27])[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1.[NH2:29][C:30]1[C:38]([Cl:39])=[CH:37][C:33](C(O)=O)=[C:32]([O:40][CH3:41])[CH:31]=1>>[NH2:29][C:30]1[C:38]([Cl:39])=[CH:37][C:33]([C:6]([NH:8][CH2:9][CH:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:26]([CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)=[O:27])[CH2:11]2)=[O:7])=[C:32]([O:40][CH3:41])[CH:31]=1

Participants

4

Reactant 3

HCID 75938Cyclohexanecarbonyl chlorideHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53780052HCID 53780052, compound

Product 1

HCID 54116413HCID 54116413, compound

Procedure

4-(3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)butylamine (1.00 g) as starting compound was reacted and treated in the same manner as in Example 1 using cyclohexanecarbonyl chloride (0.49 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (0.74 g) to give 4-amino-5-chloro-N-(1-(4-cyclohexanecarbonylaminobutyl)pyrrolidin-3-ylmethyl)-2-methoxybenzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-201b20330c3e47838cbb13dd5901d0c7
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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