Cyclohexanecarbonyl chloride → HCID 54481472, compound

HRID 344302Notes

Reaction equation

HRID 344302 reaction equation
C(O[C:6]([NH:8][CH2:9][C@H:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH2:20])[CH2:11]1)=[O:7])(C)(C)C.[CH:21]1([C:27](Cl)=[O:28])[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1.[NH2:30][C:31]1[C:39]([Cl:40])=[CH:38][C:34](C(O)=O)=[C:33]([O:41][CH3:42])[CH:32]=1>>[NH2:30][C:31]1[C:39]([Cl:40])=[CH:38][C:34]([C:6]([NH:8][CH2:9][C@H:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:27]([CH:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)=[O:28])[CH2:11]2)=[O:7])=[C:33]([O:41][CH3:42])[CH:32]=1

Participants

4

Reactant 3

HCID 75938Cyclohexanecarbonyl chlorideHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53808195HCID 53808195, compound

Product 1

HCID 54481472HCID 54481472, compound

Procedure

5-((3R)-3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)pentylamine (1.00 g) as starting compound was reacted and treated in the same manner as in Example 1 using cyclohexanecarbonyl chloride (0.52 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (0.70 g) to give 4-amino-5-chloro-N-((3R)-1-(5-cyclohexanecarbonylaminopentyl)pyrrolidin-3-ylmethyl)-2-methoxybenzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-fd4e86b798df4bd4958f536a6280183e
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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