Benzoyl chloride → HCID 57303562, compound

HRID 344306Notes

Reaction equation

HRID 344306 reaction equation
C(O[C:6]([NH:8][CH2:9][C@@H:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH2:18])[CH2:11]1)=[O:7])(C)(C)C.[C:19](Cl)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[NH2:28][C:29]1[C:37]([Cl:38])=[CH:36][C:32](C(O)=O)=[C:31]([O:39][CH3:40])[CH:30]=1>>[NH2:28][C:29]1[C:37]([Cl:38])=[CH:36][C:32]([C:6]([NH:8][CH2:9][C@@H:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH:18][C:19](=[O:26])[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:11]2)=[O:7])=[C:31]([O:39][CH3:40])[CH:30]=1

Participants

4

Reactant 3

HCID 7412Benzoyl chlorideHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53696621HCID 53696621, compound

Product 1

HCID 57303562HCID 57303562, compound

Procedure

3-((3S)-3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)propylamine (1.50 g) as starting compound was reacted and treated in the same manner as in Example 1 using benzoyl chloride (0.68 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (1.17 g) to give 4-amino-N-((3S)-1-(3-benzoylaminopropyl)pyrrolidin-3-ylmethyl)-5-chloro-2-methoxybenzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-df1f23d7709943b6ac7529f7123b871e
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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