4-Methylbenzoyl Chloride → HCID 54029282, compound

HRID 344308Notes

Reaction equation

HRID 344308 reaction equation
C(O[C:6]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH2:18])[CH2:11]1)=[O:7])(C)(C)C.[CH3:19][C:20]1[CH:28]=[CH:27][C:23]([C:24](Cl)=[O:25])=[CH:22][CH:21]=1.[NH2:29][C:30]1[C:38]([Cl:39])=[CH:37][C:33](C(O)=O)=[C:32]([O:40][CH3:41])[CH:31]=1>>[NH2:29][C:30]1[C:38]([Cl:39])=[CH:37][C:33]([C:6]([NH:8][CH2:9][CH:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH:18][C:24](=[O:25])[C:23]3[CH:27]=[CH:28][C:20]([CH3:19])=[CH:21][CH:22]=3)[CH2:11]2)=[O:7])=[C:32]([O:40][CH3:41])[CH:31]=1

Participants

4

Reactant 3

HCID 134054-Methylbenzoyl ChlorideHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53696622HCID 53696622, compound

Product 1

HCID 54029282HCID 54029282, compound

Procedure

3-(3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)propylamine (1.08 g) as starting compound was reacted and treated in the same manner as in Example 1 using 4-methylbenzoyl chloride (0.56 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (0.48 g) to give 4-amino-5-chloro-2-methoxy-N-(1-(3-(4-methylbenzoylamino)propyl)pyrrolidin-3-ylmethyl)benzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-0280007dbe1745a7af340157ab4a5939
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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