p-Anisoyl chloride → HCID 53896115, compound

HRID 344309Notes

Reaction equation

HRID 344309 reaction equation
C(O[C:6]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH2:18])[CH2:11]1)=[O:7])(C)(C)C.[O:19]([C:21]1[CH:29]=[CH:28][C:24]([C:25](Cl)=[O:26])=[CH:23][CH:22]=1)[CH3:20].[NH2:30][C:31]1[C:39]([Cl:40])=[CH:38][C:34](C(O)=O)=[C:33]([O:41][CH3:42])[CH:32]=1>>[NH2:30][C:31]1[C:39]([Cl:40])=[CH:38][C:34]([C:6]([NH:8][CH2:9][CH:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH:18][C:25](=[O:26])[C:24]3[CH:28]=[CH:29][C:21]([O:19][CH3:20])=[CH:22][CH:23]=3)[CH2:11]2)=[O:7])=[C:33]([O:41][CH3:42])[CH:32]=1

Participants

4

Reactant 3

HCID 7477p-Anisoyl chlorideHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53696622HCID 53696622, compound

Product 1

HCID 53896115HCID 53896115, compound

Procedure

3-(3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)propylamine (1.03 g) as starting compound was reacted and treated in the same manner as in Example 1 using 4-methoxylbenzoyl chloride (0.68 g) and 4-amino-5-chloro-2-methoxybenzoic acid (0.41 g) to give 4-amino-5-chloro-2-methoxy-N-(1-(3-(4-methoxybenzoylamino)propyl)pyrrolidin-3-ylmethyl)benzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-8d519edfe8dd4f29bca5fee9baa5a049
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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