Benzenesulfonyl chloride → HCID 53670474, compound

HRID 344317Notes

Reaction equation

HRID 344317 reaction equation
C(O[C:6]([NH:8][CH2:9][C@H:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH2:20])[CH2:11]1)=[O:7])(C)(C)C.[CH:21]1[CH:26]=[CH:25][C:24]([S:27](Cl)(=[O:29])=[O:28])=[CH:23][CH:22]=1.[NH2:31][C:32]1[C:40]([Cl:41])=[CH:39][C:35](C(O)=O)=[C:34]([O:42][CH3:43])[CH:33]=1>>[NH2:31][C:32]1[C:40]([Cl:41])=[CH:39][C:35]([C:6]([NH:8][CH2:9][C@H:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][S:27]([C:24]3[CH:25]=[CH:26][CH:21]=[CH:22][CH:23]=3)(=[O:29])=[O:28])[CH2:11]2)=[O:7])=[C:34]([O:42][CH3:43])[CH:33]=1

Participants

4

Reactant 3

HCID 7369Benzenesulfonyl chlorideHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53808195HCID 53808195, compound

Product 1

HCID 53670474HCID 53670474, compound

Procedure

5-((3R)-3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)pentylamine (1.00 g) as starting compound was reacted and treated in the same manner as in Example 1 using 4-benzenesulfonyl chloride (0.49 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (0.70 g) to give 4-amino-N-((3R)-1-(5-benzenesulfonylaminopentyl)pyrrolidin-3-ylmethyl)-5-chloro-2-methoxybenzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-c45394497d7e4627aab8a2cb4e03879a
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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