Ethyl isocyanate → HCID 54146573, compound

Participants

Reaction Steps

5-((3R)-3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)-pentylamine (2.0 g) was dissolved in methylene chloride (20 ml) and a solution of ethyl isocyanate (0.55 ml) in methylene chloride was dropwise added under ice-cooling. The mixture was stirred at room temperature for 0.25 hr, and the reaction mixture was concentrated under reduced pressure to give (3R)-3-tert-butoxycarbonylaminomethyl-1-(5-(3-ethylureido)pentyl)pyrrolidine.

Provenance & Evidence