Propyl isocyanate → HCID 54561597, compound

HRID 344324Notes

Reaction equation

HRID 344324 reaction equation
C(O[C:6]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][NH2:17])[CH2:11]1)=[O:7])(C)(C)C.[CH2:18]([N:21]=[C:22]=[O:23])[CH2:19][CH3:20].[NH2:24][C:25]1[C:33]([Cl:34])=[CH:32][C:28](C(O)=O)=[C:27]([O:35][CH3:36])[CH:26]=1>>[NH2:24][C:25]1[C:33]([Cl:34])=[CH:32][C:28]([C:6]([NH:8][CH2:9][CH:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][NH:17][C:22]([NH:21][CH2:18][CH2:19][CH3:20])=[O:23])[CH2:11]2)=[O:7])=[C:27]([O:35][CH3:36])[CH:26]=1

Participants

4

Reactant 3

HCID 61033Propyl isocyanateHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53652257tert-Butyl ((1-(2-aminoethyl)pyrrolidin-3-yl)methyl)carbamate

Product 1

HCID 54561597HCID 54561597, compound

Procedure

2-(3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)ethylamine (1 g) as starting compound was reacted and treated in the same manner as in Example 34 using n-propyl isocyanate (0.38 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (0.83 g) to give 4-amino-5-chloro-2-methoxy-N-(1-(2-(3-n-propylureido)ethyl)pyrrolidin-3-ylmethyl)-benzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-82d628af1aa9476f9105502c9372cf85
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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