Propyl isocyanate → HCID 53691230, compound

HRID 344325Notes

Reaction equation

HRID 344325 reaction equation
C(O[C:6]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH2:18])[CH2:11]1)=[O:7])(C)(C)C.[CH2:19]([N:22]=[C:23]=[O:24])[CH2:20][CH3:21].[NH2:25][C:26]1[C:34]([Cl:35])=[CH:33][C:29](C(O)=O)=[C:28]([O:36][CH3:37])[CH:27]=1>>[NH2:25][C:26]1[C:34]([Cl:35])=[CH:33][C:29]([C:6]([NH:8][CH2:9][CH:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH:18][C:23]([NH:22][CH2:19][CH2:20][CH3:21])=[O:24])[CH2:11]2)=[O:7])=[C:28]([O:36][CH3:37])[CH:27]=1

Participants

4

Reactant 3

HCID 61033Propyl isocyanateHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53696622HCID 53696622, compound

Product 1

HCID 53691230HCID 53691230, compound

Procedure

3-(3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)propylamine (1.1 g) as starting compound was reacted and treated in the same manner as in Example 34 using n-propyl isocyanate (0.40 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (0.87 g) to give 4-amino-5-chloro-2-methoxy-N-(1-(3-(3-n-propylureido)propyl)pyrrolidin-3-ylmethyl)benzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-e3942ea4f7634d8a975617e45ff9ec75
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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