Propyl isocyanate → HCID 53757673, compound

HRID 344326Notes

Reaction equation

HRID 344326 reaction equation
C(O[C:6]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][NH2:19])[CH2:11]1)=[O:7])(C)(C)C.[CH2:20]([N:23]=[C:24]=[O:25])[CH2:21][CH3:22].[NH2:26][C:27]1[C:35]([Cl:36])=[CH:34][C:30](C(O)=O)=[C:29]([O:37][CH3:38])[CH:28]=1>>[NH2:26][C:27]1[C:35]([Cl:36])=[CH:34][C:30]([C:6]([NH:8][CH2:9][CH:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:24]([NH:23][CH2:20][CH2:21][CH3:22])=[O:25])[CH2:11]2)=[O:7])=[C:29]([O:37][CH3:38])[CH:28]=1

Participants

4

Reactant 3

HCID 61033Propyl isocyanateHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53780052HCID 53780052, compound

Product 1

HCID 53757673HCID 53757673, compound

Procedure

4-(3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)butylamine (1.10 g) as starting compound was reacted and treated in the same manner as in Example 34 using n-propyl isocyanate (0.42 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (0.82 g) to give 4-amino-5-chloro-2-methoxy-N-(1-(4-(3-n-propylureido)butyl)pyrrolidin-3-ylmethyl)benzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-b69d46ad9fe246669f81d1929e3b824d
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

Loading…