Propyl isocyanate → HCID 56982218, compound

HRID 344330Notes

Reaction equation

HRID 344330 reaction equation
C(O[C:6]([NH:8][CH2:9][C@@H:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH2:20])[CH2:11]1)=[O:7])(C)(C)C.[CH2:21]([N:24]=[C:25]=[O:26])[CH2:22][CH3:23].[NH2:27][C:28]1[C:36]([Cl:37])=[CH:35][C:31](C(O)=O)=[C:30]([O:38][CH3:39])[CH:29]=1>>[NH2:27][C:28]1[C:36]([Cl:37])=[CH:35][C:31]([C:6]([NH:8][CH2:9][C@@H:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:25]([NH:24][CH2:21][CH2:22][CH3:23])=[O:26])[CH2:11]2)=[O:7])=[C:30]([O:38][CH3:39])[CH:29]=1

Participants

4

Reactant 3

HCID 61033Propyl isocyanateHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53808197HCID 53808197, compound

Product 1

HCID 56982218HCID 56982218, compound

Procedure

5-((3S)-3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)pentylamine (1.50 g) as starting compound was reacted and treated in the same manner as in Example 34 using n-propyl isocyanate (0.49 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (0.61 g) to give 4-amino-5-chloro-2-methoxy-N-((3S)-1-(5-(3-n-propylureido)pentyl)pyrrolidin-3-ylmethyl)benzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-ab8cee761a904df3a0556a73779860d9
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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