反应详情

5-(4-tert-Butoxycarbonylaminomethylpiperidin-1-yl)pentylamine (1.1 g) was dissolved in methylene chloride (20 ml) and a solution of n-propyl isocyanate (0.34 ml) in methylene chloride was dropwise added under ice-cooling. The mixture was stirred at room temperature for 1 hr, and the reaction mixture was concentrated under reduced pressure to give 4-tert-butoxycarbonylaminomethyl-1-(5-(3-n-propylureido)pentyl)piperidine.

1. temperaturecooling
2. concentrationthe reaction mixture was concentrated under reduced pressure