Propyl isocyanate → HCID 54276629, compound

HRID 344332Notes

Reaction equation

HRID 344332 reaction equation
C(O[C:6]([NH:8][CH2:9][C@H:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][NH2:21])[CH2:11]1)=[O:7])(C)(C)C.[CH2:22]([N:25]=[C:26]=[O:27])[CH2:23][CH3:24].[NH2:28][C:29]1[C:37]([Cl:38])=[CH:36][C:32](C(O)=O)=[C:31]([O:39][CH3:40])[CH:30]=1>>[NH2:28][C:29]1[C:37]([Cl:38])=[CH:36][C:32]([C:6]([NH:8][CH2:9][C@H:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][NH:21][C:26]([NH:25][CH2:22][CH2:23][CH3:24])=[O:27])[CH2:11]2)=[O:7])=[C:31]([O:39][CH3:40])[CH:30]=1

Participants

4

Reactant 3

HCID 61033Propyl isocyanateHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53706156HCID 53706156, compound

Product 1

HCID 54276629HCID 54276629, compound

Procedure

6-((3R)-3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)hexylamine (1.50 g) as starting compound was reacted and treated in the same manner as in Example 34 using n-propyl isocyanate (0.50 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (1.01 g) to give 4-amino-5-chloro-2-methoxy-N-((3R)-1-(6-(3-n-propylureido)hexyl)pyrrolidin-3-ylmethyl)benzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-e6b65d8b49be44fab550ca5bfe521ca3
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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