Phenyl isocyanate → HCID 53734561, compound

HRID 344338Notes

Reaction equation

HRID 344338 reaction equation
C(O[C:6]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH2:20])[CH2:11]1)=[O:7])(C)(C)C.[C:21]1([N:27]=[C:28]=[O:29])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.[NH2:30][C:31]1[C:39]([Cl:40])=[CH:38][C:34](C(O)=O)=[C:33]([O:41][CH3:42])[CH:32]=1>>[NH2:30][C:31]1[C:39]([Cl:40])=[CH:38][C:34]([C:6]([NH:8][CH2:9][CH:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:28]([NH:27][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[O:29])[CH2:11]2)=[O:7])=[C:33]([O:41][CH3:42])[CH:32]=1

Participants

4

Reactant 3

HCID 7672Phenyl isocyanateHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53808196HCID 53808196, compound

Product 1

HCID 53734561HCID 53734561, compound

Procedure

5-(3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)pentylamine (0.87 g) as starting compound was reacted and treated in the same manner as in Example 34 using phenyl isocyanate (0.33 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (0.63 g) to give 4-amino-5-chloro-2-methoxy-N-(1-(5-(3-phenylureido)pentyl)pyrrolidin-3-ylmethyl)-benzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-599ee721e6934f35ba5e505c2729fad4
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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