Methyl isothiocyanate → HCID 54547589, compound

HRID 344346Notes

Reaction equation

HRID 344346 reaction equation
C(O[C:6]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][NH2:19])[CH2:11]1)=[O:7])(C)(C)C.[CH3:20][N:21]=[C:22]=[S:23].[NH2:24][C:25]1[C:33]([Cl:34])=[CH:32][C:28](C(O)=O)=[C:27]([O:35][CH3:36])[CH:26]=1>>[NH2:24][C:25]1[C:33]([Cl:34])=[CH:32][C:28]([C:6]([NH:8][CH2:9][CH:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:22]([NH:21][CH3:20])=[S:23])[CH2:11]2)=[O:7])=[C:27]([O:35][CH3:36])[CH:26]=1

Participants

4

Reactant 3

HCID 11167Methyl isothiocyanateHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53780052HCID 53780052, compound

Product 1

HCID 54547589HCID 54547589, compound

Procedure

4-(3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)butylamine (1.01 g) as starting compound was reacted and treated in the same manner as in Example 34 using methyl isothiocyanate (0.28 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (0.82 g) to give 4-amino-5-chloro-2-methoxy-N-(1-(4-(3-methylthioureido)butyl)pyrrolidin-3-ylmethyl)benzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-86133cc2a6d842b5803ebe32b3980f58
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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