4-Amino-5-chloro-2-methoxybenzoic acid → 4-amino-5-chloro-N-(1-(3-(2,3-dihydro-1,3-dioxo-1 H-isoindol-2-yl)propyl)-pyrrolidin-3-ylmethyl)-2-methoxybenzamide

Participants

Reaction Steps

2-(3-(3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)propyl)-2,3-dihydro-1 H-isoindole-1,3-dione (1 g) as starting compound was reacted and treated in the same manner as in Example 67 using 4-amino-5-chloro-2-methoxybenzoic acid (0.50 g) to give 4-amino-5-chloro-N-(1-(3-(2,3-dihydro-1,3-dioxo-1 H-isoindol-2-yl)propyl)-pyrrolidin-3-ylmethyl)-2-methoxybenzamide.

Provenance & Evidence