4-Amino-5-chloro-2-methoxybenzoic acid → HCID 53831127, compound

HRID 344351Notes

Reaction equation

HRID 344351 reaction equation
[NH2:1][C:2]1[C:26]([Cl:27])=[CH:25][C:5]([C:6]([NH:8][CH2:9][CH2:10][N:11]2[CH2:15][CH2:14][CH:13]([CH2:16][NH:17][C:18]([O:20]C(C)(C)C)=O)[CH2:12]2)=[O:7])=[C:4]([O:28][CH3:29])[CH:3]=1.[NH2:30][C:31]1[C:39]([Cl:40])=[CH:38][C:34](C(O)=O)=[C:33]([O:41][CH3:42])[CH:32]=1>>[NH2:30][C:31]1[C:39]([Cl:40])=[CH:38][C:34]([C:18]([NH:17][CH2:16][CH:13]2[CH2:14][CH2:15][N:11]([CH2:10][CH2:9][NH:8][C:6](=[O:7])[C:5]3[CH:25]=[C:26]([Cl:27])[C:2]([NH2:1])=[CH:3][C:4]=3[O:28][CH3:29])[CH2:12]2)=[O:20])=[C:33]([O:41][CH3:42])[CH:32]=1

Participants

3

Reactant 2

HCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53758917HCID 53758917, compound

Product 1

HCID 53831127HCID 53831127, compound

Procedure

4-Amino-N-(2-(3-tert-butoxycarbonylaminomethylpyrrolidin-1-yl)-ethyl)-5-chloro-2-methoxybenzamide (0.97 g) as starting compound was reacted and treated in the same manner as in Example 67 using 4-amino-5-chloro-2-methoxybenzoic acid (0.50 g) to give 4-amino-N-(1-(2-(4-amino-5-chloro-2-methoxybenzoylamino)ethyl)pyrrolidin-3-ylmethyl)-5-chloro-2-methoxybenzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-6b6031a51ed643af80400218ffd20e0f
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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