4-Amino-5-chloro-2-methoxybenzoic acid → HCID 54518956, compound

HRID 344352Notes

Reaction equation

HRID 344352 reaction equation
[NH2:1][C:2]1[C:27]([Cl:28])=[CH:26][C:5]([C:6]([NH:8][CH2:9][CH2:10][CH2:11][N:12]2[CH2:16][CH2:15][CH:14]([CH2:17][NH:18][C:19]([O:21]C(C)(C)C)=O)[CH2:13]2)=[O:7])=[C:4]([O:29][CH3:30])[CH:3]=1.[NH2:31][C:32]1[C:40]([Cl:41])=[CH:39][C:35](C(O)=O)=[C:34]([O:42][CH3:43])[CH:33]=1>>[NH2:31][C:32]1[C:40]([Cl:41])=[CH:39][C:35]([C:19]([NH:18][CH2:17][CH:14]2[CH2:15][CH2:16][N:12]([CH2:11][CH2:10][CH2:9][NH:8][C:6](=[O:7])[C:5]3[CH:26]=[C:27]([Cl:28])[C:2]([NH2:1])=[CH:3][C:4]=3[O:29][CH3:30])[CH2:13]2)=[O:21])=[C:34]([O:42][CH3:43])[CH:33]=1

Participants

3

Reactant 2

HCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53866133HCID 53866133, compound

Product 1

HCID 54518956HCID 54518956, compound

Procedure

4-Amino-N-(3-(3-tert-butoxycarbonylaminomethylpyrrolidin-1-yl)-propyl)-5-chloro-2-methoxybenzamide (1.70 g) as starting compound was reacted and treated in the same manner as in Example 67 using 4-amino-5-chloro-2-methoxybenzoic acid (0.76 g) to give 4-amino-N-(1-(3-(4-amino-5-chloro-2-methoxybenzoylamino)propyl)pyrrolidin-3-ylmethyl)-5-chloro-2-methoxybenzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-0a6e5abb953047e08077c173b1dd5a6f
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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