4-Amino-5-chloro-2-methoxybenzoic acid → 4-amino-N-(1-(4-(4-amino-5-chloro-2-methoxybenzoylamino)butyl)pyrrolidin-3-ylmethyl)-5-chloro-2-methoxybenzamide

HRID 344353Notes

Reaction equation

HRID 344353 reaction equation
[NH2:1][C:2]1[C:28]([Cl:29])=[CH:27][C:5]([C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]2[CH2:17][CH2:16][CH:15]([CH2:18][NH:19][C:20]([O:22]C(C)(C)C)=O)[CH2:14]2)=[O:7])=[C:4]([O:30][CH3:31])[CH:3]=1.[NH2:32][C:33]1[C:41]([Cl:42])=[CH:40][C:36](C(O)=O)=[C:35]([O:43][CH3:44])[CH:34]=1>>[NH2:32][C:33]1[C:41]([Cl:42])=[CH:40][C:36]([C:20]([NH:19][CH2:18][CH:15]2[CH2:16][CH2:17][N:13]([CH2:12][CH2:11][CH2:10][CH2:9][NH:8][C:6](=[O:7])[C:5]3[CH:27]=[C:28]([Cl:29])[C:2]([NH2:1])=[CH:3][C:4]=3[O:30][CH3:31])[CH2:14]2)=[O:22])=[C:35]([O:43][CH3:44])[CH:34]=1

Participants

3

Reactant 2

HCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 542718254-Amino-N-(4-(3-tert-butoxycarbonylaminomethylpyrrolidin-1-yl)-butyl)-5-chloro-2-methoxybenzamide

Product 1

HCID 537074144-amino-N-(1-(4-(4-amino-5-chloro-2-methoxybenzoylamino)butyl)pyrrolidin-3-ylmethyl)-5-chloro-2-methoxybenzamide

Procedure

4-Amino-N-(4-(3-tert-butoxycarbonylaminomethylpyrrolidin-1-yl)-butyl)-5-chloro-2-methoxybenzamide (1.35 g) as starting compound was reacted and treated in the same manner as in Example 67 using 4-amino-5-chloro-2-methoxybenzoic acid (0.60 g) to give 4-amino-N-(1-(4-(4-amino-5-chloro-2-methoxybenzoylamino)butyl)pyrrolidin-3-ylmethyl)-5-chloro-2-methoxybenzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-07bd5263dea6432aa150634eb6238b21
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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