4-Amino-5-chloro-2-methoxybenzoic acid → HCID 54160943, compound

HRID 344357Notes

Reaction equation

HRID 344357 reaction equation
C(O[C:6]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]2[C:30]3[O:29][CH2:28][CH2:27][N:26]([CH3:31])[C:25]=3[CH:24]=[C:23]([Cl:32])[CH:22]=2)=[O:20])[CH2:11]1)=[O:7])(C)(C)C.[NH2:33][C:34]1[C:42]([Cl:43])=[CH:41][C:37](C(O)=O)=[C:36]([O:44][CH3:45])[CH:35]=1>>[NH2:33][C:34]1[C:42]([Cl:43])=[CH:41][C:37]([C:6]([NH:8][CH2:9][CH:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]3[C:30]4[O:29][CH2:28][CH2:27][N:26]([CH3:31])[C:25]=4[CH:24]=[C:23]([Cl:32])[CH:22]=3)=[O:20])[CH2:11]2)=[O:7])=[C:36]([O:44][CH3:45])[CH:35]=1

Participants

3

Reactant 2

HCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53972172HCID 53972172, compound

Product 1

HCID 54160943HCID 54160943, compound

Procedure

N-(3-(3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)propyl)-6-chloro-4-methyl-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide (1.5 g) as starting compound was reacted and treated in the same manner as in Example 67 using 4-amino-5-chloro-2-methoxybenzoic acid (0.65 g) to give N-(3-(3-(4-amino-5-chloro-2-methoxybenzoylaminomethyl)-pyrrolidin-1-yl)propyl)-6-chloro-4-methyl-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-6bbba670dc9446be835ac6ff20d72965
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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