4-Amino-5-chloro-2-methoxybenzoic acid → HCID 53947736, compound

HRID 344358Notes

Reaction equation

HRID 344358 reaction equation
C(O[C:6]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:20]([C:22]2[C:31]3[O:30][CH2:29][CH2:28][N:27]([CH3:32])[C:26]=3[CH:25]=[C:24]([Cl:33])[CH:23]=2)=[O:21])[CH2:11]1)=[O:7])(C)(C)C.[NH2:34][C:35]1[C:43]([Cl:44])=[CH:42][C:38](C(O)=O)=[C:37]([O:45][CH3:46])[CH:36]=1>>[NH2:34][C:35]1[C:43]([Cl:44])=[CH:42][C:38]([C:6]([NH:8][CH2:9][CH:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:20]([C:22]3[C:31]4[O:30][CH2:29][CH2:28][N:27]([CH3:32])[C:26]=4[CH:25]=[C:24]([Cl:33])[CH:23]=3)=[O:21])[CH2:11]2)=[O:7])=[C:37]([O:45][CH3:46])[CH:36]=1

Participants

3

Reactant 2

HCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53830936HCID 53830936, compound

Product 1

HCID 53947736HCID 53947736, compound

Procedure

N-(4-(3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)butyl)-6-chloro-4-methyl-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide (0.7 g) as starting compound was reacted and treated in the same manner as in Example 67 using 4-amino-5-chloro-2-methoxybenzoic acid (0.37 g) to give N-(4-(3-(4-amino-5-chloro-2-methoxybenzoylaminomethyl)-pyrrolidin-1-yl)butyl)-6-chloro-4-methyl-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-460a9fa59ea744eeb9d8ee68154c1595
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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