4-Amino-5-chloro-2-methoxybenzoic acid → HCID 54330977, compound

HRID 344359Notes

Reaction equation

HRID 344359 reaction equation
C(O[C:6]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][NH:17][C:18]([C:20]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[N:22]([CH3:29])[CH:21]=2)=[O:19])[CH2:11]1)=[O:7])(C)(C)C.[NH2:30][C:31]1[C:39]([Cl:40])=[CH:38][C:34](C(O)=O)=[C:33]([O:41][CH3:42])[CH:32]=1>>[NH2:30][C:31]1[C:39]([Cl:40])=[CH:38][C:34]([C:6]([NH:8][CH2:9][CH:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][NH:17][C:18]([C:20]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[N:22]([CH3:29])[CH:21]=3)=[O:19])[CH2:11]2)=[O:7])=[C:33]([O:41][CH3:42])[CH:32]=1

Participants

3

Reactant 2

HCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53716617HCID 53716617, compound

Product 1

HCID 54330977HCID 54330977, compound

Procedure

N-(2-(3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)ethyl)-1-methyl-1 H-indole-3-carboxamide (2.16 g) as starting compound was reacted and treated in the same manner as in Example 67 using 4-amino-5-chloro-2-methoxybenzoic acid (1.1 g) to give N-(2-(3-(4-amino-5-chloro-2-methoxybenzoylaminomethyl)pyrrolidin-1-yl)ethyl)-1-methyl-1 H-indole-3-carboxamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-dd3d3873734b4c6db0960ceb4d2f311c
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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