4-Amino-5-chloro-2-methoxybenzoic acid → HCID 54568396, compound

HRID 344360Notes

Reaction equation

HRID 344360 reaction equation
C(O[C:6]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]2[C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[N:23]([CH3:30])[CH:22]=2)=[O:20])[CH2:11]1)=[O:7])(C)(C)C.[NH2:31][C:32]1[C:40]([Cl:41])=[CH:39][C:35](C(O)=O)=[C:34]([O:42][CH3:43])[CH:33]=1>>[NH2:31][C:32]1[C:40]([Cl:41])=[CH:39][C:35]([C:6]([NH:8][CH2:9][CH:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]3[C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[N:23]([CH3:30])[CH:22]=3)=[O:20])[CH2:11]2)=[O:7])=[C:34]([O:42][CH3:43])[CH:33]=1

Participants

3

Reactant 2

HCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53644847HCID 53644847, compound

Product 1

HCID 54568396HCID 54568396, compound

Procedure

N-(3-(3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)propyl)-1-methyl-1 H-indole-3-carboxamide (0.44 g) as starting compound was reacted and treated in the same manner as in Example 67 using 4-amino-5-chloro-2-methoxybenzoic acid (0.26 g) to give N-(3-(3-(4-amino-5-chloro-2-methoxybenzoylaminomethyl)pyrrolidin-1-yl)propyl)-1-methyl-1H-indole-3-carboxamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-96756dbfb06d4d2f84dc96409928a4d8
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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