4-Amino-5-chloro-2-methoxybenzoic acid → HCID 53913682, compound

HRID 344361Notes

Reaction equation

HRID 344361 reaction equation
C(OC([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:20]([C:22]2[C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[N:24]([CH3:31])[CH:23]=2)=[O:21])[CH2:11]1)=O)(C)(C)C.[NH2:32][C:33]1[C:41]([Cl:42])=[CH:40][C:36]([C:37]([OH:39])=O)=[C:35]([O:43][CH3:44])[CH:34]=1>>[NH2:32][C:33]1[C:41]([Cl:42])=[CH:40][C:36]([C:37]([NH:8][CH2:9][CH:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:20]([C:22]3[C:30]4[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=4)[N:24]([CH3:31])[CH:23]=3)=[O:21])[CH2:11]2)=[O:39])=[C:35]([O:43][CH3:44])[CH:34]=1

Participants

3

Reactant 2

HCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53881695HCID 53881695, compound

Product 1

HCID 53913682HCID 53913682, compound

Procedure

N-(4-(3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)butyl)-1-methyl-1 H-indole-3-carboxamide (0.67 g) as starting compound was reacted and treated in the same manner as in Example 67 using 4-amino-5-chloro-2-methoxybenzoic acid (0.42 g) to give N-(4-(3-(4-amino-5-chloro-2-methoxybenzoylaminomethyl)pyrrolidin-1-yl)butyl)-1-methyl-1 H-indole-3-carboxamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-97fa1d06634246b2968037d2176042e8
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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