4-Amino-5-chloro-2-methoxybenzoic acid → HCID 54238730, compound

HRID 344364Notes

Reaction equation

HRID 344364 reaction equation
C(O[C:6]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21]([C:23]2[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[N:25]([CH3:32])[CH:24]=2)=[O:22])[CH2:11]1)=[O:7])(C)(C)C.[NH2:33][C:34]1[C:42]([Cl:43])=[CH:41][C:37](C(O)=O)=[C:36]([O:44][CH3:45])[CH:35]=1>>[NH2:33][C:34]1[C:42]([Cl:43])=[CH:41][C:37]([C:6]([NH:8][CH2:9][CH:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21]([C:23]3[C:31]4[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=4)[N:25]([CH3:32])[CH:24]=3)=[O:22])[CH2:11]2)=[O:7])=[C:36]([O:44][CH3:45])[CH:35]=1

Participants

3

Reactant 2

HCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 54080148HCID 54080148, compound

Product 1

HCID 54238730HCID 54238730, compound

Procedure

N-(5-(3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)pentyl)-1-methyl-1 H-indole-3-carboxamide (0.89 g) as starting compound was reacted and treated in the same manner as in Example 67 using 4-amino-5-chloro-2-methoxybenzoic acid (0.42 g) to give N-(5-(3-(4-amino-5-chloro-2-methoxybenzoylaminomethyl)pyrrolidin-1-yl)pentyl)-1-methyl-1 H-indole-3-carboxamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-2ae5488352074a838e551f0fb5a6fb73
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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