4-Amino-5-chloro-2-methoxybenzoic acid → HCID 54239115, compound

HRID 344370Notes

Reaction equation

HRID 344370 reaction equation
C(O[C:6]([NH:8][CH2:9][C@H:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:20]([C:22]2[N:23]([CH3:31])[C:24]3[C:29]([CH:30]=2)=[CH:28][CH:27]=[CH:26][CH:25]=3)=[O:21])[CH2:11]1)=[O:7])(C)(C)C.[NH2:32][C:33]1[C:41]([Cl:42])=[CH:40][C:36](C(O)=O)=[C:35]([O:43][CH3:44])[CH:34]=1>>[NH2:32][C:33]1[C:41]([Cl:42])=[CH:40][C:36]([C:6]([NH:8][CH2:9][C@H:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:20]([C:22]3[N:23]([CH3:31])[C:24]4[C:29]([CH:30]=3)=[CH:28][CH:27]=[CH:26][CH:25]=4)=[O:21])[CH2:11]2)=[O:7])=[C:35]([O:43][CH3:44])[CH:34]=1

Participants

3

Reactant 2

HCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53720206HCID 53720206, compound

Product 1

HCID 54239115HCID 54239115, compound

Procedure

N-(4-((3R)-3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)-butyl)-1-methyl-1 H-indole-2-carboxamide (0.95 g) as starting compound was reacted and treated in the same manner as in Example 67 using 4-amino-5-chloro-2-methoxybenzoic acid (0.45 g) to give N-(4-((3R)-3-(4-amino-5-chloro-2-methoxybenzoylaminomethyl)pyrrolidin-1-yl)butyl)-1-methyl-1 H-indole-2-carboxamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-504341a0aa8d4a5688db8ae2416bef58
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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