4-Amino-5-chloro-2-methoxybenzoic acid → HCID 54430520, compound

HRID 344377Notes

Reaction equation

HRID 344377 reaction equation
C(O[C:6]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][N:18]2[C:22](=[O:23])[C:21]3[CH:24]=[CH:25][CH:26]=[CH:27][C:20]=3[S:19]2(=[O:29])=[O:28])[CH2:11]1)=[O:7])(C)(C)C.[NH2:30][C:31]1[C:39]([Cl:40])=[CH:38][C:34](C(O)=O)=[C:33]([O:41][CH3:42])[CH:32]=1>>[NH2:30][C:31]1[C:39]([Cl:40])=[CH:38][C:34]([C:6]([NH:8][CH2:9][CH:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][N:18]3[C:22](=[O:23])[C:21]4[CH:24]=[CH:25][CH:26]=[CH:27][C:20]=4[S:19]3(=[O:28])=[O:29])[CH2:11]2)=[O:7])=[C:33]([O:41][CH3:42])[CH:32]=1

Participants

3

Reactant 2

HCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 54048557HCID 54048557, compound

Product 1

HCID 54430520HCID 54430520, compound

Procedure

3-tert-Butoxycarbonylaminomethyl-1-(3-(1,1,3-trioxo-2,3-dihydro-1,2-benzisothiazol-2-yl)propyl)pyrrolidine (0.28 g) as starting compound was reacted and treated in the same manner as in Example 67 using 4-amino-5-chloro-2-methoxybenzoic acid (0.13 g) to give 4-amino-5-chloro-2-methoxy-N-(1-(3-(1,1,3-trioxo-2,3-dihydro-1,2-benzisothiazol-2-yl)propyl)pyrrolidin-3-ylmethyl)benzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-18a52288d6b248efaf71375e6f52ed76
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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