4-Amino-5-chloro-2-methoxybenzoic acid → HCID 53836559, compound

HRID 344378Notes

Reaction equation

HRID 344378 reaction equation
C(O[C:6]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][N:18]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[NH:20][C:19]2=[O:27])[CH2:11]1)=[O:7])(C)(C)C.[NH2:28][C:29]1[C:37]([Cl:38])=[CH:36][C:32](C(O)=O)=[C:31]([O:39][CH3:40])[CH:30]=1>>[NH2:28][C:29]1[C:37]([Cl:38])=[CH:36][C:32]([C:6]([NH:8][CH2:9][CH:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][N:18]3[C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=4[NH:20][C:19]3=[O:27])[CH2:11]2)=[O:7])=[C:31]([O:39][CH3:40])[CH:30]=1

Participants

3

Reactant 2

HCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53849970HCID 53849970, compound

Product 1

HCID 53836559HCID 53836559, compound

Procedure

3-tert-Butoxycarbonylaminomethyl-1-(3-(2,3-dihydro-2-oxobenzimidazol-1-yl)propyl)pyrrolidine (1.31 g) as starting compound was reacted and treated in the same manner as in Example 67 using 4-amino-5-chloro-2-methoxybenzoic acid (0.7 g) to give 4-amino-5-chloro-N-(1-(3-(2,3-dihydro-2-oxobenzimidazol-1-yl)propyl)pyrrolidin-3-ylmethyl)-2-methoxybenzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-1175a43129664fd5bb240352660fcd26
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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