Phenyl isocyanate → Benzamide

Participants

Reaction Steps

4-Amino-N-(1-(6-aminohexyl)piperidin-4-ylmethyl)-5-chloro-2-methoxybenzamide (1.00 g) was dissolved in dimethylformamide (15 ml). A solution of phenyl isocyanate (0.30 ml) in methylene chloride was dropwise added under ice-cooling. The mixture was stirred at room temperature for 12 hr. and the reaction mixture was concentrated under reduced pressure. The obtained residue was purified by silica gel chromatography to give 0.30 g of 4-amino-5-chloro-2-methoxy-N-(1-(6-phenylureido)hexyl)piperidin-4-ylmethyl)benzamide.

Provenance & Evidence