Hydrazine hydrate (1:1) → 4-amino-N-(1-(4-aminobutyl)piperidin-4-ylmethyl)-5-chloro-2-methoxybenzamide

Participants

Reaction Steps

4-Amino-5-chloro-N-(1-(4-(2,3-dihydro-1,3-dioxo-1H-isoindol-2-yl)butyl)piperidin-4-ylmethyl)-2-methoxybenzamide (9.3 g) as starting compound and hydrazine monohydrate (1.4 ml) were reacted and treated in the same manner as in Example 117 to give 6.9 g of 4-amino-N-(1-(4-aminobutyl)piperidin-4-ylmethyl)-5-chloro-2-methoxybenzamide. m.p. 104°-107° C.

Provenance & Evidence