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Hydrazine hydrate (1:1) → 4-Amino-N-(1-(6-aminohexyl)piperidin-4-ylmethyl)-5-chloro-2-methoxybenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | 4-amino-5-chloro-N-(1-(6-(2,3-dihydro-1,3-dioxo-1H-isoindol-2-yl)hexyl)-piperidin-4-ylmethyl)-2-methoxybenzamide | HCID 54520676 | — |
| 生成物 | 4-Amino-N-(1-(6-aminohexyl)piperidin-4-ylmethyl)-5-chloro-2-methoxybenzamide | HCID 53683637 | 112.7% |
反応手順
4-Amino-5-chloro-N-(1-(6-(2,3-dihydro-1,3-dioxo-1 H-isoindol-2-yl)hexyl)piperidin-4-ylmethyl)-2-methoxybenzamide (15.9 g) as starting compound and hydrazine monohydrate (2.2 ml) were reacted and treated in the same manner as in Example 117 to give 13.5 g of 4-amino-N-(1-(6-aminohexyl)piperidin-4-ylmethyl)-5-chloro-2-methoxybenzamide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05864039 |
| 出典データセット | uspto-grants-1999_01 |
| ORD ID | ord-f945036bc7814c629ca548b08477c3f5 |
| 出典メモ | uspto-grants-1999_01 |