1-Methyl-1H-indole-3-carbaldehyde → HCID 70075898, compound

HRID 344403Notes

Reaction equation

HRID 344403 reaction equation
[NH2:1][C:2]1[C:23]([Cl:24])=[CH:22][C:5]([C:6]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][NH2:21])[CH2:12][CH2:11]2)=[O:7])=[C:4]([O:25][CH3:26])[CH:3]=1.[CH3:27][N:28]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[C:30]([CH:37]=O)=[CH:29]1>>[NH2:1][C:2]1[C:23]([Cl:24])=[CH:22][C:5]([C:6]([NH:8][CH2:9][CH:10]2[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][NH:21][CH2:37][C:30]3[C:31]4[C:36](=[CH:35][CH:34]=[CH:33][CH:32]=4)[N:28]([CH3:27])[CH:29]=3)[CH2:14][CH2:15]2)=[O:7])=[C:4]([O:25][CH3:26])[CH:3]=1

Participants

3

Reactant 2

HCID 878941-Methyl-1H-indole-3-carbaldehydeHCID 540083634-Amino-N-(1-(5-aminopentyl)piperidin-4-ylmethyl)-5-chloro-2-methoxybenzamide

Product 1

HCID 70075898HCID 70075898, compoundYield 48.5%

Procedure

4-Amino-N-(1-(5-aminopentyl)piperidin-4-ylmethyl)-5-chloro-2-methoxybenzamide (1.5 g) as starting compound and 1-methyl-1 H-indol-3-carboxaldehyde (0.81 g) were reacted and treated in the same manner as in Example 121 to give 1.0 g of 4-amino-5-chloro-N-((1-(5-((1-methyl-1 H-indol-3-ylmethyl)amino)pentyl)piperidin-4-yl)methyl)-2-methoxybenzamide.

Workup

  1. customwere reacted
  2. additiontreated in the same manner as in Example 121

Sources & evidence

ORD record
ord-e77b6ea813cc4c53bf36eaa3c897df45
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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