4-Methylbenzaldehyde → HCID 54453222, compound

HRID 344405Notes

Reaction equation

HRID 344405 reaction equation
[NH2:1][C:2]1[C:24]([Cl:25])=[CH:23][C:5]([C:6]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][NH2:22])[CH2:12][CH2:11]2)=[O:7])=[C:4]([O:26][CH3:27])[CH:3]=1.[CH3:28][C:29]1[CH:36]=[CH:35][C:32]([CH:33]=O)=[CH:31][CH:30]=1>>[NH2:1][C:2]1[C:24]([Cl:25])=[CH:23][C:5]([C:6]([NH:8][CH2:9][CH:10]2[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][NH:22][CH2:28][C:29]3[CH:36]=[CH:35][C:32]([CH3:33])=[CH:31][CH:30]=3)[CH2:14][CH2:15]2)=[O:7])=[C:4]([O:26][CH3:27])[CH:3]=1

Participants

3

Reactant 2

HCID 77254-MethylbenzaldehydeHCID 536836374-Amino-N-(1-(6-aminohexyl)piperidin-4-ylmethyl)-5-chloro-2-methoxybenzamide

Product 1

HCID 54453222HCID 54453222, compoundYield 42.4%

Procedure

4-Amino-N-(1-(6-aminohexyl)piperidin-4-ylmethyl)-5-chloro-2-methoxybenzamide (2.0 g) as starting compound and 4-methylbenzaldehyde (0.66 g) were reacted and treated in the same manner as in Example 121 to give 1.07 g of 4-amino-5-chloro-2-methoxy-N-((1-(6-(4-methylbenzylamino)hexyl)piperidin-4-yl)methyl)benzamide.

Workup

  1. customwere reacted
  2. additiontreated in the same manner as in Example 121

Sources & evidence

ORD record
ord-f0b888ee55754b74bec144536efb5d76
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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