HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzaldehyde → 4-amino-5-chloro-N-((1-(5-dibenzylaminopentyl)piperidin-4-yl)methyl)-2-methoxybenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 4-amino-N-((1-(5-benzylaminopentyl)piperidin-4-yl)methyl)-5-chloro-2-methoxybenzamide | HCID 54015496 | — |
| Product | 4-amino-5-chloro-N-((1-(5-dibenzylaminopentyl)piperidin-4-yl)methyl)-2-methoxybenzamide | HCID 53704519 | 22.7% |
Reaction Steps
4-Amino-N-((1-(5-benzylaminopentyl)piperidin-4-yl)methyl)-5-chloro-2-methoxybenzamide (1.11 g) as starting compound, benzaldehyde (0.28 g) and sodium cyanoborohydride (0.33 g) were reacted and treated in the same manner as in Example 136 to give 0.3 g of 4-amino-5-chloro-N-((1-(5-dibenzylaminopentyl)piperidin-4-yl)methyl)-2-methoxybenzamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05864039 |
| Source dataset | uspto-grants-1999_01 |
| ORD ID | ord-b5270396d9b048a385d6c7b5120fd537 |
| Source note | uspto-grants-1999_01 |