HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Difluorobenzene → HCID 54574047, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Difluorobenzene | HCID 9706 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6-Bromohexanoyl chloride | HCID 89848 | — |
| Reactant | HCID 53698228 | HCID 53698228 | — |
| Reactant | 4-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride | HCID 69966330 | — |
| Product | HCID 54574047 | HCID 54574047 | 28.7% |
Reaction Steps
4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride (0.57 g) as starting compound, potassium carbonate (0.82 g), and 6-bromo-1-(3,4-difluorophenyl)-1-hexanone (0.42 g) obtained by subjecting 6-bromohexanoyl chloride and 1,2-difluorobenzene to Friedel-Crafts reaction were reacted and treated in the same manner as in Example 172 to give 0.21 g of 4-amino-5-chloro-N-((1-(6-(3,4-difluorophenyl)-6-oxohexyl)piperidin-4-yl)methyl)-2-methoxybenzamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05864039 |
| Source dataset | uspto-grants-1999_01 |
| ORD ID | ord-9058f4c226fe4b7cb881bf264b7d1be7 |
| Source note | uspto-grants-1999_01 |