Potassium Carbonate → 4-amino-5-chloro-N-((1-(6-(3-chloro-4-methoxyphenyl)-6-oxohexyl)-piperidin-4-yl)methyl)-2-methoxybenzamide

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	6-Bromo-1-(3-chloro-4-methoxyphenyl)-1-hexanone	HCID 54451623	—
Reactant	4-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride	HCID 69966330	—
Product	4-amino-5-chloro-N-((1-(6-(3-chloro-4-methoxyphenyl)-6-oxohexyl)-piperidin-4-yl)methyl)-2-methoxybenzamide	HCID 53812928	36.2%

Reaction Steps

4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride (0.86 g) as starting compound, potassium carbonate (2.0 g) and 6-bromo-1-(3-chloro-4-methoxyphenyl)-1-hexanone (0.82 g) were reacted and treated in the same manner as in Example 172 to give 0.45 g of 4-amino-5-chloro-N-((1-(6-(3-chloro-4-methoxyphenyl)-6-oxohexyl)-piperidin-4-yl)methyl)-2-methoxybenzamide.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05864039
Source dataset	uspto-grants-1999_01
ORD ID	ord-8453334b1809452ba7ba6e58ebe9e8dd
Source note	uspto-grants-1999_01