HRID344486

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID54113253

未命名化合物

结构：COc1cc(N)c(Cl)cc1C(=O)NCC1CCNCC1.Cl.Cl

HCID69966330

未命名化合物

PRODUCTS

生成物

结构：COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCC(=O)c2cn(C)c3ccc(Cl)cc23)CC1

HCID54567591

未命名化合物

PROCEDURE

实验过程

4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride as starting compound and 6-bromo-1-(5-chloro-1-methyl-1 H-indol-3-yl)-1-hexanone are reacted and treated in the same manner as in Example 199 to give 4-amino-5-chloro-2-methoxy-N-((1-(6-(5-chloro-1-methyl-1 H-indol-3-yl)-6-oxohexyl)piperidin-4-yl)methyl)benzamide.

WORKUP

后处理

customare reacted
additiontreated in the same manner as in Example 199

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-dceaf4ca4fef4e0f839aa6fa775ba913
来源数据集: uspto-grants-1999_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05864039
来源说明: uspto-grants-1999_01

反应 SMILES

Cl.Cl.[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1.Br[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][C:29]([C:31]1[C:39]2[C:34](=[CH:35][CH:36]=[C:37]([Cl:40])[CH:38]=2)[N:33]([CH3:41])[CH:32]=1)=[O:30]>>[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:13][CH2:14][N:15]([CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][C:29]([C:31]3[C:39]4[C:34](=[CH:35][CH:36]=[C:37]([Cl:40])[CH:38]=4)[N:33]([CH3:41])[CH:32]=3)=[O:30])[CH2:16][CH2:17]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1