[(5-Bromopentyl)thio]benzene → HCID 44216284, 화합물

HRID 344509노트

반응식

HRID 344509 반응식
Cl.Cl.[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1.[C:23]1([S:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]Br)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:13][CH2:14][N:15]([CH2:34][CH2:33][CH2:32][CH2:31][CH2:30][S:29][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH2:16][CH2:17]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1

참가 물질

3

반응물 2

HCID 12272162[(5-Bromopentyl)thio]benzeneHCID 699663304-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride

생성물 1

HCID 44216284HCID 44216284, 화합물수율 27.3%

실험 절차

4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride (2.00 g) as starting compound and 5-phenylthiopentyl bromide (1.54 g) were reacted and treated in the same manner as in Example 168 to give 0.70 g of 4-amino-5-chloro-2-methoxy-N-((1-(5-phenylthiopentyl)piperidin-4-yl)methyl)benzamide.

후처리

  1. customwere reacted
  2. additiontreated in the same manner as in Example 168

출처 및 근거

ORD 기록
ord-dbd509517efa4ce5842cf43dc76fdcf0
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05864039

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