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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 344523Generated: October 30, 2026

1-((5-Bromopentyl)oxy)-4-chlorobenzene → 4-amino-5-chloro-N-((1-(5-(4-chlorophenoxy)pentyl)-piperidin-4-yl)methyl)-2-methoxybenzamide

https://huagongshe.com/reaction/344523

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-((5-Bromopentyl)oxy)-4-chlorobenzeneHCID 2794894—
Reactant4-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochlorideHCID 69966330—
Product4-amino-5-chloro-N-((1-(5-(4-chlorophenoxy)pentyl)-piperidin-4-yl)methyl)-2-methoxybenzamideHCID 53844929—

Reaction Steps

4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride (1.3 g) as starting compound and 5-(4-chlorophenoxy)-pentyl bromide (1.0 g) were reacted and treated in the same manner as in Example 168 to give 4-amino-5-chloro-N-((1-(5-(4-chlorophenoxy)pentyl)-piperidin-4-yl)methyl)-2-methoxybenzamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05864039
Source datasetuspto-grants-1999_01
ORD IDord-702e42f7d7ed4b15904cd86446fe29c6
Source noteuspto-grants-1999_01