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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 344525Generated: October 25, 2026

1-(4-Bromobutoxy)naphthalene → 4-amino-5-chloro-N-((1-(4-(1-naphthyloxy)butyl)piperidin-4-yl)methyl)-2-methoxybenzamide

https://huagongshe.com/reaction/344525

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(4-Bromobutoxy)naphthaleneHCID 12958270—
Reactant4-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochlorideHCID 69966330—
Product4-amino-5-chloro-N-((1-(4-(1-naphthyloxy)butyl)piperidin-4-yl)methyl)-2-methoxybenzamideHCID 53947300—

Reaction Steps

4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride as starting compound and 4-(1-naphthyloxy)butyl bromide are reacted and treated in the same manner as in Example 168 to give 4-amino-5-chloro-N-((1-(4-(1-naphthyloxy)butyl)piperidin-4-yl)methyl)-2-methoxybenzamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05864039
Source datasetuspto-grants-1999_01
ORD IDord-8a4f04ca22b84f74bd9ac9328d7c76d4
Source noteuspto-grants-1999_01