HCID 43165190, compound → HCID 53899166, compound

HRID 344527Notes

Reaction equation

HRID 344527 reaction equation
Cl.Cl.[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1.[CH2:23]1[O:31][C:30]2[CH:29]=[CH:28][C:27]([CH2:32][O:33][CH2:34][CH2:35][CH2:36][CH2:37]Br)=[CH:26][C:25]=2[O:24]1>>[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:13][CH2:14][N:15]([CH2:37][CH2:36][CH2:35][CH2:34][O:33][CH2:32][C:27]3[CH:28]=[CH:29][C:30]4[O:31][CH2:23][O:24][C:25]=4[CH:26]=3)[CH2:16][CH2:17]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1

Participants

3

Reactant 2

HCID 43165190HCID 43165190, compoundHCID 699663304-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride

Product 1

HCID 53899166HCID 53899166, compound

Procedure

4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride as starting compound and 4-((3,4-methylenedioxyphenyl)methoxy)butyl bromide are reacted and treated in the same manner as in Example 168 to give 4-amino-5-chloro-N-((1-(4-((3,4-methylenedioxyphenyl)methoxy)butyl)piperidin-4-yl)methyl)-2-methoxybenzamide.

Workup

  1. customare reacted
  2. additiontreated in the same manner as in Example 168

Sources & evidence

ORD record
ord-45b9955de2a84e5f9eb37dfa6a3780e5
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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