(2-Bromoethanesulfonyl)benzene → HCID 70076536, compound

HRID 344545Notes

Reaction equation

HRID 344545 reaction equation
Cl.Cl.[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1.[C:23]1([S:29]([CH2:32][CH2:33]Br)(=[O:31])=[O:30])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[ClH:20].[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:13][CH2:14][N:15]([CH2:33][CH2:32][S:29]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)(=[O:30])=[O:31])[CH2:16][CH2:17]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1

Participants

3

Reactant 2

HCID 12518322(2-Bromoethanesulfonyl)benzeneHCID 699663304-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride

Product 1

HCID 70076536HCID 70076536, compoundYield 57.8%

Procedure

4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride (7 g) and 2-(phenylsulfonyl)ethyl bromide (5.6 g) were reacted and treated in the same manner as in Example 199 to give 2.74 g of 4-amino-5-chloro-2-methoxy-N-((1-(2-(phenylsulfonyl)ethyl)-piperidin-4-yl)methyl)benzamide hydrochloride.

Workup

  1. additiontreated in the same manner as in Example 199

Sources & evidence

ORD record
ord-48d1e7c9a2f04fdfbec15fc228bca79a
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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