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HRID344545

反应详情

EQUATION

反应方程式

HRID 344545 的结构方程式

REACTANTS

反应物

2
结构：O=S(=O)(CCBr)c1ccccc1
HCID12518322

(2-Bromoethanesulfonyl)benzene

C8H9BrO2S

结构：COc1cc(N)c(Cl)cc1C(=O)NCC1CCNCC1.Cl.Cl
HCID69966330

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCS(=O)(=O)c2ccccc2)CC1.Cl
HCID70076536

未命名化合物

收率 57.8%

PROCEDURE

实验过程

4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride (7 g) and 2-(phenylsulfonyl)ethyl bromide (5.6 g) were reacted and treated in the same manner as in Example 199 to give 2.74 g of 4-amino-5-chloro-2-methoxy-N-((1-(2-(phenylsulfonyl)ethyl)-piperidin-4-yl)methyl)benzamide hydrochloride.

WORKUP

后处理

  1. additiontreated in the same manner as in Example 199