Potassium Carbonate → 4-amino-5-chloro-2-methoxy-N-((1-(2-benzylsulfonylethyl)piperidin-4-yl)methyl)-benzamide

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	(((2-Chloroethyl)sulfonyl)methyl)benzene	HCID 99230	—
Reactant	4-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride	HCID 69966330	—
Product	4-amino-5-chloro-2-methoxy-N-((1-(2-benzylsulfonylethyl)piperidin-4-yl)methyl)-benzamide	HCID 54051652	88.6%

Reaction Steps

4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride (1.50 g) as a starting compound, 2-benzylsulfonylethyl chloride (1.21 g) and potassium carbonate (1.54 g) were reacted and treated in the same manner as in Example 199 to give 1.72 g of 4-amino-5-chloro-2-methoxy-N-((1-(2-benzylsulfonylethyl)piperidin-4-yl)methyl)-benzamide,

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05864039
Source dataset	uspto-grants-1999_01
ORD ID	ord-6f2ca228842f44ec84aec0c4972e930c
Source note	uspto-grants-1999_01