HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-amino-5-chloro-2-methoxy-N-((1-(3-(4-methoxybenzyl)-sulfonylpropyl)piperidin-4-yl)methyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride | HCID 69966330 | — |
| Reactant | 3-(4-Methoxybenzyl)-sulfonylpropyl chloride | HCID 86753639 | — |
| Product | 4-amino-5-chloro-2-methoxy-N-((1-(3-(4-methoxybenzyl)-sulfonylpropyl)piperidin-4-yl)methyl)benzamide | HCID 86753638 | 54% |
Reaction Steps
4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride (10.0 g) as a starting compound, 3-(4-methoxybenzyl)-sulfonylpropyl chloride (8.50 g) and potassium carbonate (16.8 g) were reacted and purified in the same manner as in Example 199 to give 7.60 g of 4-amino-5-chloro-2-methoxy-N-((1-(3-(4-methoxybenzyl)-sulfonylpropyl)piperidin-4-yl)methyl)benzamide, m.p. 111°-112° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05864039 |
| Source dataset | uspto-grants-1999_01 |
| ORD ID | ord-fee8f642aee64d61b35f396dfdd3ade9 |
| Source note | uspto-grants-1999_01 |