1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 54106656, compound

Participants

Reaction Steps

4-Aminomethyl-1-(3-(4-hydroxyphenyl)-3-oxopropyl)piperidine dihydrobromide (9.00 g) as a starting compound, 4-amino-5-chloro-2-methoxybenzoic acid (4.28 g), triethylamine (8.82 ml), 1-hydroxybenzotriazole (3.00 g) and 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (4.27 g) were reacted and purified in the same manner as in Example 270 to give 3.40 g of 4-amino-5-chloro-2-methoxy-N-((1-(3-(4-hydroxyphenyl)-3-oxopropyl)piperidin-4-yl)methyl)benzamide, m.p. 191°-193° C.

Provenance & Evidence