HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 70074745, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 4-Amino-5-chloro-2-methoxybenzoic acid | HCID 81626 | — |
| Reactant | HCID 70075020 | HCID 70075020 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 70074745 | HCID 70074745 | 107.8% |
Reaction Steps
4-Aminomethyl-1-(6-(2-hydroxyphenyl)-6-oxohexyl)piperidine dihydrochloride (1.54 g) as a starting compound, 4-amino-5-chloro-2-methoxybenzoic acid (0.82 g), triethylamine (1.7 ml), 1-hydroxybenzotriazole (0.58 g) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (0.82 g) were reacted and purified in the same manner as in Example 270 to give 1.15 g of 4-amino-5-chloro-2-methoxy-N-((1-(6-(2-hydroxyphenyl)-6-oxohexyl)piperidin-4-yl)methyl)benzamide hydrochloride, m.p. 143°-145° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05864039 |
| Source dataset | uspto-grants-1999_01 |
| ORD ID | ord-95f411cc87f643669b55be6607560bb0 |
| Source note | uspto-grants-1999_01 |